Interaction of Complement and Polymyxin with Gram-Negative Bacteria

Interaction of complement and polymyxin with gram-negative bacteria.

The interaction of complement and polymyxin with gram-negative bacteria has been investigated by using three strains of Salmonella typhimurium in an attempt to determine the loci of complement action. It has been shown that the bactericidal activities of complement and polymyxin towards a smooth gram-negative organism are similarly affected by various components of the bactericidal test system....

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria

Polymyxin combination therapy is increasingly used clinically. However, systematic investigations of such combinations are a relatively recent phenomenon. The emerging pharmacodynamic (PD) and pharmacokinetic (PK) data on CMS/colistin and polymyxin B suggest that caution is required with monotherapy. Given this situation, polymyxin combination therapy has been suggested as a possible way to inc...

Polymyxin B Hemoperfusion Improves Hemodynamic Status in Patients with Sepsis with Both Gram-Negative and Non-Gram-Negative Bacteria

Background: Direct hemoperfusion with a polymyxin B (PMX) often produces improvement in patients with sepsis caused by bacteria other than those classified as gramnegative. The aim of the present study is to clarify the therapeutic effects of PMX in patients with sepsis caused by bacteria other than gram-negative bacteria. Methods and Findings: We enrolled 41 patients with severe sepsis includi...

Synthesis and Characterization of Novel Antibacterial PDDA/Honey Nanofiber Against Gram-Positive and Gram-Negative Bacteria

Nanomaterials are increasingly used to the targeting of gram-positive and gram-negative bacteria as an alternative to antibiotics. Bacterial infections are a major cause of chronic infections and mortality. People requirement for new materials for pathogenic bacteria treatment. It seems that nanomaterial-based strategies can be resolving this problem. In this research, improved antibacterial na...

Cell Envelope Structure and Functions in Gram-negative Bacteria